Genetic Basis of Human Brain

Selected Reading There is also the question of why the absence of IRC is enough to cause mortality. ROS have been widely Basset, A., Khush, R.S., Braun, A., Gardan, L., Boccard, F., Hoffstudied for their role in signaling, tissue injury, regulation mann, J.A., and Lemaitre, B. (2000). Proc. Natl. Acad. Sci. USA of vascular tone, and control of inflammation. High levels 97, 3376–3381. of ROS have been implicated in long-term effects like Basset, A., Tzou, P., Lemaitre, B., and Boccard, F. (2003). EMBO aging and DNA damage (reviewed in Fang, 2004). But Rep. 4, 205–210. what makes the ROS so toxic to flies? Is the oxidative Brandt, S.M., Dionne, M.S., Khush, R.S., Pham, L.N., Vigdal, T.J., stress enough to induce tissue damage and death? Or and Schneider, D.S. (2004). PLoS Biol. 2(12), e418 10.1371/journal.pbio.0020418. are the ROS involved in signaling to specific mechanisms that initiate programmed cell death? Recent literaDe Gregorio, E., Spellman, P.T., Rubin, G.M., and Lemaitre, B. (2001). Proc. Natl. Acad. Sci. USA 98, 12590–12595. ture shows other evidence of immune-induced signaling Fang, F.C. (2004). Nat. Rev. Microbiol. 2, 820–832. molecules having a harmful effect on fly survival (Brandt